منابع مشابه
DNA Methylation and Its Role in the Development of Leukemia
Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...
متن کاملDNA methylation of tumor suppressor genes in hepatocellular carcinoma
The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
متن کاملdna-directed methylation analysis methodology
epigenetics alterations, especially dna methylation, play a critical role in control of gene expressions. abnormal patterns of methylation are observed in early-stages of many cancers. therefore, methylation analysis is useful in primary detection of tumors. advances knowledge about the functional role of aberrant epigenetic modifications as potential biomarkers for cancer, have attracted consi...
متن کاملThe role and importance of DNA methylation in spermatogenesis process
Background: DNA methylation is one of the epigenetic marks that are created by de novo DNA methylation and be maintained through cell division. This process is catalyzed by DNA methyltransferases. DNA methylation establishment in germ line is important, since they have the potential to regulate gene expression in offspring and improper DNA methylation patterns in germ lines has serious conseque...
متن کاملDNA methylation.
SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC) has generated much interest and considerable controversy during attempts to understand its significance (for review, see Weissbach1). DNA methylation in eukaryotes involves addition of a methyl group to the carbon 5 position of the cytosine ring (Fig 1). This reaction is catalyzed by DNA methyltransferase ...
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ژورنال
عنوان ژورنال: EcoSal Plus
سال: 2013
ISSN: 2324-6200
DOI: 10.1128/ecosalplus.esp-0003-2013